Introduction: Cerebral palsy is the most common childhood disability Aims: Analyze and determine the main risk factors for the development of cerebral palsy in the population of Kazakhstan Materials and methods: Retrospective, analytical "case" - "control". Core group "case" - medical records of 100 pregnant women whose children at different ages has been diagnosed with cere-bral palsy Results: Thus, a retrospective analysis revealed the following features and complications in the perinatal period, which could promote the formation of cerebral palsy in children. Analytical results of the study are set significant results in cerebral palsy development Conclusion: Premature birth and urinary tract infections turned out to be the largest contribu-tors to the development of cerebral palsy, however, according to statistics, the rate of preterm birth, as well as the detection of infections, stably remains at the same level, while the number of cerebral palsy has been steadily growing since the early 1990s in Kazakhstan.

According to WHO, the frequency of infertility ranges from 15-18% and has no tendency to decrease. In many countries with the widespread introduction of IVF, the number of newborns born after ART has been steadily increasing. A prospective analysis of the features of the course of the early neonatal period of newborns born after IVF was carried out. The number of babies born at a full term gestation of 85% is growing; most newborns were born in satisfactory condition on the Apgar scale. The high frequency (10%) of congenital heart defects in newborns born after the use of ART is noteworthy. The results require further efforts to reduce the number of preterm births, to study the follow-up of children to establish the relationship between the health problems of children born after ART.

В данном обзоре на основании литературных данных изучен ряд биомаркеров и определена их связь с развитием преэклампсии у женщин с прегестационным сахарным диабетом в I триместре беременности. В связи с тем, что в основе этих состояний лежат схожие механизмы, ранняя диагностика преэклампсии у данной категории пациенток значительно затруднена. Выполнена оценка материнских факторов риска, биофизических и биохимических маркеров, показана их роль в предикции преэклампсии. Установлено, что при наличии сахарного диабета исследование некоторых гормонов, маркеров воспалительной реакции, метаболизма липидов может иметь потенциальную ценность для прогнозирования развития преэклампсии. Таким образом, для активного внедрения биомаркеров в практическую деятельность требуются дальнейшее, более детальное изучение этого направления и оптимизация дизайна исследований. In this review, based on the literature data, a number of biomarkers have been studied and their relationship with the development of preeclampsia in women with pregestational diabetes mellitus in the first trimester of pregnancy has been determined. Due to the fact that these conditions are based on similar mechanisms, early diagnosis of preeclampsia in this category of patients is significantly difficult. The assessment of maternal risk factors, biophysical and biochemical markers was carried out, their role in the prediction of preeclampsia was shown. It has been established that in the presence of diabetes mellitus, the study of certain hormones, markers of the inflammatory response, lipid metabolism may be of potential value for predicting the development of preeclampsia. Thus, for the active introduction of biomarkers into practice, further, more detailed study of this area and optimization of research design are required.

A retrospective analysis was carried out according to the archival material of the center of perinatology and pediatric cardiac surgery in Almaty for 2017-2018. The analysis was carried out in 2 groups: the main group - 250 histories of women giving birth after IVF and the comparative group - 250 histories of women giving birth to spontaneous pregnancy. The condition of the feto-placental complex was assessed by studying the data of ultrasound, Dopplerometry, CTG, histological examination. The study shows that in women after the use of ART, the absence of pronounced blood flow disorders in the mother-placenta-fetus system according to Dopple-rometry is important and significant, which contributes to the favorable course of pregnancy and the state of the fetus, as well as the presence of morphological signs of placental insufficiency in 68% of cases inflammatory changes in the placenta in 57% of cases of varying severity.

A retrospective analysis was carried out according to the archival material of the center of perinatology and pediatric cardiac surgery in Almaty for 2020. The analysis was carried out in pregnant women with COVID-19, a total of 150 stories were examined. The features of the course of pregnancy and childbirth were assessed by studying the data of laboratory diagnostic methods of research, clinical symptoms, X-ray, ultrasound, Doppler studies. The study highlights the features of pregnancy, childbirth and the postpartum period in women infected with COVID-19.