Buschke-Löwenstein tumor (BLT), known as giant condyloma acuminatum (GCA), is a very rare disease that typically appears as a penile lesion but can although appear in the anogenital region, bladder, vulva, scrotum and sacrococcygeal area as well. Despite of its histologically benign signs, a high recurrence rate, invasiveness and destructive growth characterizes this rare disease as clinically malignant. Malignant transformation into verrucous carcinoma (VC) and squamous-cell carcinoma (SCC) have been described as well. Many treatment modalities inclusive neoadjuvant radio-and chemotherapy and topical treatment have been reported but due to lack of controlled studies no treatment can be recommended. We present a case of Buschke-Löwenstein tumor involving the right lower abdominal wall of the colostomy region at a 71 years old male. To our knowledge, we first describe a case report of GCA involving abdominal wall at the colostomy region, successfully treated by wide radical excision and plastic reconstruction.