Data on the natural course of gastrooesophageal reflux disease are sparse. One hundred and sixty six patients with typical reflux symptoms (heartburn and/or acid regurgitation) and pathologic pH monitoring (reflux time >8*2% upright and/or >3*0% supine) were studied.The patients were followed up by questionnaire and interview for a mean of 41 (seven to 86) months after diagnosis of reflux disease.

Treatment with azelaic acid 20 % cream significantly improves acne severity and disease-related QoL in adult women.

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Die Anwendung von 20%iger Azelainsäure-Creme führt bei erwachsenen Frauen zu einer signifikanten Besserung der Acne vulgaris und der krankheitsbedingten Lebensqualität.