Utilizing data from a cross-sectional community survey of 455 heterosexual couples in which at least one partner has a physical disability, we examine the associations between stigma and psychological distress for both partners. We also assess whether these associations are moderated by gender. Findings from an actor-partner interdependence model analysis reveal that personally experienced stigma and vicarious stigma experiences have additive effects on psychological distress, but only among women. We discuss how these findings extend a relational understanding of stigma and its effects and implications for research and practice.