No abstract

Background: Leucine can stimulate insulin release, but the mechanism has remained unclear. Results: Leucine regulates adrenergic ␣2 receptor trafficking. Rapamycin and clonidine together increase the risk of diabetes. Conclusion: mTOR activation by leucine elicits insulin release via adrenergic ␣2 receptors. Rapamycin and clonidine appear to synergistically facilitate new-onset diabetes. Significance: Our findings may have relevance in the clinical management of renal transplant patients.

No abstract

Tangier disease is a rare autosomal recessive disease resulting in cholesterol deposition in different organs. We report a case of a 52year-old white man who presented for chronic diarrhea without significant findings on noninvasive testing. Subsequent colonoscopy revealed endoscopically normal mucosa, with random biopsies remarkable for foamy macrophages in the lamina propria. Genetic testing showed adenosine triphosphate-binding cassette transporter gene mutation with low high-density lipoprotein and low lowdensity lipoprotein. To the best of our knowledge, this is the first report of chronic diarrhea in a patient with Tangier disease without any other clear etiology.

No abstract