The Budd-Chiari syndrome (BCS) is a rare life threatening and clinically challenging disorder defined by obstruction of hepatic venous outflow anywhere from the small hepatic veins to the suprahepatic inferior vena cava. It is considered as a manifestation of underlying prothrombotic risk factors of which myeloproliferative disorders are the most common ones. We describe a 41year old Male who presented with bilateral lower limb edema and abdominal distension with visible veins over the anterior abdomen which on further evaluation was diagnosed as Budd-chiari syndrome. Budd Chiari syndrome requires a prompt and accurate diagnosis with an aggressive treatment which depends on the cause, clinical presentation and anatomical location of the problem.

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2351be used to determine whether the regulatory functions of HIF-1α are either direct or indirect.

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