Indonesian people had long used plants as traditional medicine. In addition to maintaining health, traditional medicine was in great demand and prevents disease. We often encounter syzygium polyanthum leaves as a complement in tamarind and pepes, which were believed to act as a preservative. This study aimed to determine qualitatively bay leaf extract as an antimicrobial, Salmonella typhi. Methanol extraction of syzygium polyantum leaves would be partitioned with hexane and ethyl acetate solvents. The anti-microbial potential was shown in the Maximum Inhibitory Concentration (MIC) test, the identification of the compound using GC-MS and its potential as antibacterial was shown by docking the molecule using docking in silico technique against 5L3J protein. The MIC results were shown that the hexane partition at 100 ppm had 22.09 mm inhibition and the ethyl acetate partition at 80 ppm, had 18.15 mm inhibition. The GC-MS’ testing  resulted of syzygium polianthum leaf extract showed the presence of alpha-pinene, alpha-cubenene, 1H-Cyclopropa [a] naphthalene, nerolidol, humulene epoxide II, phytol, 9,12,15-Octadecatrien-1-ol, Squalene, Alpha-tocopherol, Beta-sitosterol, azulene, valence, Azulene and beta-Panasinen. However, the lowest binding affinity value was obtained from the cytosterol compound of −9.45 kcal/mol in ethyl acetate and Valencene solutions of −6.93 kcal/mol in n-hexane solvent. While the positive control-Chloramphenicol was −36.93 kcal/mol. This means that the syzygium polyanthum leaf extract could be used as an alternative medicine for typhoid. GRAPHICAL ABSTRACT