Aquaculture has become a worldwide economically important industry which requires continuing research with scientific and technical developments and innovations (Bektaş et al., 2017).To cover the increasing need of food in the World, an intensive production in fisheries has been a must which ended with the occurrence of diseases (FAO, 2016). The fact that aquaculture sector is the fastest growing food-production industry in the world is plagued by diseases. The annual economic loss in the aquaculture industry due to diseases is estimated to be billions of US dollars worldwide (Klesius and Pridgeon, 2011). The development of intensive aquaculture has led to the emergence of various bacterial diseases (Pridgeon and Klesius, 2012). Infectious disease outbreaks in fish farms might be caused by single or multiple pathogens; however, little is known about the association of different microorganisms causing coinfections and its consequences (Dong et al., 2015a , 2015b).