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Background: Ultrasonography is a diagnostic method for determining the diagnosis of various diseases. It is non-invasive, nonionizing and very cost effective diagnostic in compare to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scan.Similarly contrast enhanced Ultrasonography (CEUSG) uses contrast agents used intravenously and sometimes intravesically in some cases which improve the diagnostic sensitivity, specificity and accuracy. Conclusion:Contrast-enhanced Ultrasonography (CEUSG) has a prominent role in lesion characterization with a diagnostic accuracy comparable with CT and MRI scan. CEUSG is a fast, cheap and widely used technique in most of the oncological diseases with additional benefit of lack of nephrotoxicity and radiation.