Bullous pemfigoid (BP), an autoimmune disorder, can also be induced by some medications. Vildagliptin is a new drug used to treat diabetes mellitus (DM). Recently, a few cases of vildagliptin-induced BP have been described in the literature. We report a patient with BP in which vildagliptin was thought to be as a possible causative agent. The awareness of BP development risk during gliptin therapy can prevent unnecessary usage of systemic drugs with serious side effects.

Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory disease of follicular epithelium; many comorbidities occur that disrupt the quality of life of patients. Amyloidosis is one of them. We present a case with systemic amyloidosis secondary to HS and responding positively to secukinumab therapy. Secukinumab may also be an important option for amyloidosis findings in HS patients.

Introduction: Systemic comorbidities are quite common in psoriasis, which is a chronic inflammatory disease. These comorbidities are important causes of mortality and morbidity. Atherosclerosis and related cardiovascular events are important causes of death at an early age. Atherosclerosis is a condition that can be detected by radiological examination. We aimed to evaluate the role of serum sortilin as possible markers for subclinical atherosclerosis in patients with psoriasis. Methods: Serum levels of sotilin was measured by ELISA in 33 psoriasis patients and in 33 healthy controls. Waist circumference and body mass index of both groups were recorded; Fasting plasma glucose(FPG), HOMA-IR, serum lipid and sortilin levels were measured. Carotid and femoral intima-media thicknesses (CIMT, FIMT) were measured by USG. Demographic characteristics, the severity of psoriasis (PASI), age of onset, total duration and presence of nail involvement of patients included in the study were recorded. Results: The mean serum sortilin level was 6.20 ± 3.11 ng / mL in the patient group and 7.82 ± 4.97 ng / mL in the control group. There was no statistically significant difference between serum sortilin levels in both groups (p = 0.729). There was no statistically significant relationship between serum levels of sortilin and disease severity (p = 0.597). The right and left CIMT values of the patients were significantly higher than the controls (p = 0.012, p = 0.020). There was no significant difference between the two groups in terms of FIMT values. There was a statistically significant relationship between serum sortilin levels and right CIMT in patients (p = 0.031). Discussion: The positive correlation between the level of sortilin and the right CIMT in our patient group confirmed that sortilin may be an indicator of subclinical atherosclerosis in psoriasis patients.

Introduction: Numerous dermatoses associated with monoclonal gammopathy have been reported in the literature. Subepidermal autoimmune bullous diseases (SABD) are one of them which were not common. Here we report a case of SABD associated with MGUS who had a severe mucosal involvement and unexpected positive direct Nikolsky phenomenon. Case presentation: A 68-year-old male patient was admitted to our clinic with erosions on the oral mucosa, tense blisters, erosions, and ulcers on the trunk and extremities. Subepidermal vesicle formation was detected in the skin biopsy. Clinical examination revealed positivity for the Nikolsky phenomenon. The disease was unresponsive to conventional treatments and dysphagia and hoarseness occurred. The patient was screened for malignancy due to his unresponsiveness to the treatments and his severe oral mucosal involvement. Ig-G MGUS was detected in the patient. Discussion: The Nikolsky sign is an indicator of acantholysis and is known as a specific finding for pemphigus. However, when we look at gammopathy-associated autoimmune bullous dermatoses, skin fragility has been reported in cases. However, the meaning of fragility is not explained. The diagnosis of all these patients was Ig-M MGUS. Our patient was presented because of non-IgM MGUS, direct Nikolsky positivity, and severe mucosal involvement. Conclusion: Nikolsky positivity may be a clue for gammopathy-related subepidermal autoimmune bullous diseases.