No abstract

The first reversed phase high performance liquid chromatographic method for Stability Indicating of, Azilsartan and chlorthalidone has been developed and validated to be a simple, sensitive, rapid, specific, precise, and accurate method. Chromatographic separation was achieved on Zorbax XBD-C8, 250mm × 4.6mm,5µm.Buffer pH5.5 : Methanol  (60:40) as a mobile phase at flow rate of 1 ml/min. UV detection was operated at 234 nm and injection volum was 25 μl.. The proposed method showed good linearity, accuracy, precision and was successfully applied for determination of the drugs in laboratory prepared pharmaceutical dosage forms. Keywords: Azilsartan and chlorthalidone, RP-HPLC, Stability Indicating.

Vildagliptin is approved by USFDA in 2007. Vildagliptin s- l-[n-(3-hydroxy-1-adamantyl) glycyl] pyrrolidine-2- carbonitrile is associate degree oral antihyperglycaemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (dpp-4) substance category of medicine. The present work categorical the new easy, accurate, precise analytical methodology for the determination of vildagliptin in bulk and pharmaceutical indefinite quantity kind. Analytical techniques play a decisive role by providing solutions like improvement. This paper could be a review and classification of the various analytical techniques that are the foremost widely-used in determination common provision issues. Pharmaceutical analysis plays an awfully outstanding conspicuous role in quality assurance similarly as internal control of bulk medication and pharmaceutical formulations. Fast increase in pharmaceutical industries and production of drug in numerous components of the globe has brought an increase in demand for brand new analytical techniques within the pharmaceutical industries. As a consequence, analytical methodology development has become the essential activity of study. Recent development in analytical ways has been resulted from the advancement of analytical instruments.

No abstract

No abstract