In order to achieve the goal of rapid response, effective controland protection of life inlarge-scale radiation events, the IAEA Manual 2011 has been revised based on the data of radio-sensitivity, dose-rate findings. Analyze individual differences in radiation sensitivity using 60 Co radiation (0.27 Gy/min). Chromosomal aberrations with different irradiation dose rates were used to establish the biological dose curve and analyze the excess of the "dicentric + ring" caused by the dose rate at each dose point; DAPI-images and Metafer 4 were used to capture metaphase images and make further analysis. The data were collected in 2020, Dicentric + ring/100 Cells was 17.5-43.8, the average value was28.32 ± 6.98. The mean value of Dicentric + ring/100 Cells was 31.37 in males while 25.27 in females, there are significant differences (p < .01). The irradiation dose is dominant, At each dose point, the value of"(dicentric chromosome + centric rings)/cell" is proportional to "dose rate", that is, Y = kx + b, within the dose range of 1-5 Gy, "(dicentric chromosome + centric rings)/ Cell" holds a quadratic linear relationship with dose rate, that is, y = ax 2 + bx + c; The DAPI-images might give you more hints than those of conventional Giemsa-stain.The authors recommend that the IAEA Manual 2011 could be revised based on data of radio-sensitivity and dose-rate, which may contribute to the establishment of a unified dose-response calibration curve and stimulation of potential for automation in cytogenetic biodosimetry. (1) Individual differences of radiosensitivity are very large. (2) At each dose point, "(dicentric chromosome + centric rings)/cell" is proportional to "dose rate", that is, Y = kx + b. (3) "(dicentric chromosome + centric rings)/Cell" is a quadratic linear relationship with dose rate, that is, y = ax 2 + bx + c.(4) We created a "Unity Standard Curve of Biological Dose Estimation". Creating a Unity Standard Curve of Biological Dose, under these circumstances, we can form a joint and rapid response to a nuclear and radiological accident.

Objective To explore the sensitivity index of radiation injury of radiation workers was analyzed and investigate whether the body changes and radiation doses of workers exposed to low-dose radiation have a dose-effect relationship. Methods The occupational health monitoring data of radiology staff were analyzed by retrospectively. Results Individual dose monitoring data, interventional radiology workers had the highest average cumulative annual dose, 0.86mSv. Lens opacity has a high detection rate, Compared with the control group, the lymphocyte count was increased. Annual cumulative dose reached 2.04 mSv, and single cycle average dose reached 1.62 mSv, dicentric chromosome was detected. Conclusions Radiation workers have certain radiation damage, and the focus is on those engaged in interventional radiology. The chromosome aberration rate was highest in people with more than 20 years of working life. Annual cumulative dose reached 2.04 mSv, and single cycle average dose reached 1.62 mSv, dicentric chromosome was detected, it suggests that the chromosome aberration analysis is an important index in occupational health monitoring of radiological workers.