A series of novel 2‐amino‐4‐aryl thiazoles were synthesized from α‐chloroacetophenone and thiourea at room temperature using acetone as solvent. The structures of synthesized compounds were confirmed by spectral data. All the compounds were evaluated for antitubercular activity by macro broth dilution method against Mycobacterium Tuberculosis H37Rv as standard strain. The synthesized compound displays notable antitubercular activity.

A series of imidazo[1,2-a]pyridines were synthesized by the reaction of α-chloroacetophenone and 2- aminopyridine under catalyst and solvent free condition. The synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral data. These imidazo[1,2-a]pyridines were screened for antiinflammatory activity by carrageenan induced rat hind paw edema model. Good anti-inflammatory activity was shown by few compounds. The antibacterial activity was studied against two Grampositive bacteria S. aureus and B. subtilis, two Gram-negative bacteria E. coli and S. typhi and antifungal activity against P. chrysogenum, F. moneliforme, A. flavus and A. niger. All the synthesized compounds were desplayed good antimicrobial and antifungal activities. Some of the compounds were shown higher antibacterial activity than reference drug penicillin.

2‐Arylquinoxalines were synthesized by the condensation of α‐chloroacetophenone and o‐phenylenediamine (1:1) using pyridine as catalyst in THF at room temperature. All the compounds were characterized by spectral data. Furthermore, these are screened for in vivo anti‐inflammatory activity by carrageenan induced rat hind paw edema methods all the compounds were displayed significant anti‐inflammatory activity. The title compounds were also shown good antibacterial and antifungal activity.

Schiff bases have been synthesized by the condensation of primary aryl amine with acetophenones under solvent free condition. The reaction is catalyzed by natural acid found unripe mango. This reaction is very simple and has many benefits because of cheap catalyst, good yield of product, simple experimental conditions and easily available natural products. The products were identified by various spectroscopic techniques.

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