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: The current study was framed to evaluate the anti diabetic activity of falvonoids isolated from the leaves and rhizomes of Rhus mysorensis. Anti diabetic effects of these flavonoids were screened using in vitro and in vivo models. The in vitro anti diabetic activity was screened using enzyme assay. The in vivo anti diabetic activity was screened in albino diabetic induced rats. The inhibition of α-amylase and α-glucosidase by the isolated compounds were found in concentration dependent manner. The high inhibition was found at 150 mg/mL concentration. Among the compounds screened, 2-(3,4-dihydroxyphenyl)-hydroxy-4H-chromen-4-one and 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one showed significant enzyme inhibitory effects. the fasting blood glucose levels are increased 0 hour to 7 days of treatment. Animals of the groups VII, VIII, IX, XIII, XIV,-hydroxy-4H-chromen-4-one and 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one at 100, 150, 200 mg/mL) significant reduction in the blood glucose levels after prolonged treatment (P<0.001). we noticed that compounds 2-(3,4-dihydroxyphenyl)-hydroxy-4H-chromen-4-one and 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one started to reduce the glucose levels significantly from 14 days of treatment was comparable to blood glucose levels of animals treated with standard drug glibenclamide.

Objective: The present study’s is to develop floating drug delivery system of repaglinide. Methods: Moringa gum, Repaglinide, HPMC K100M, Sodium alginate, Calcium Carbonate, Sodium Citrate. The obtained formulation was evaluated for drug content, pH, in vitro gelling capacity, in vitro buoyancy studies, and in vitro dissolution studies. Results and Discussion: All the total F1-F12 formulations showed pH ranging from 5.1 to 7.9, floating lag time of F1-F12 ranging from 5 s to 12 s with total floating time greater than 12 h, viscosity of F1-F12 ranging from 619 to 3856 cp, drug content of F1-F12 ranging from 31.2% to 93.1%, and percent drug release of F1-F12 ranging from 78.9% to 93.9%. Dissolution studies showed that F12 formulation-containing drug (30 mg) and polymer (4000 mg) showed 93.9% drug release in 12 h which is said to be optimized. Thus, the best formulation (F12) was subjected for a 3-month period of stability studies found to be stable and reported no significant change. Conclusion: The study’s goal is to develop and evaluate floating in situ gel forming solution of repaglinide with moringa gum as rate retardant polymer.

Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. Medicinal plants have been long lastingly recognized as potential sources of natural drugs. The present study was framed to evaluate anti-inflammatory activity of the compounds isolated from Rhus mysorensis. The study was carried out using in vitro and in vivo methods. In vitro anti inflammatory activity of isolated compounds was screened using egg albumin. The inhibition of protein denaturation was found to be high 90.5, 84.1with the compounds 2 and 4 at 100µg/mL respectively. Compounds 2 and 4 found active in reducing the paw volume 0.88±0.26, 1.35±0.11 at fourth hour of treatment.