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Higher education resource structure optimization is a dynamic process involving multiple factors such as target, environment, power and operation mechanism. These factors interact with each other to influence the optimization degree, direction and final effect of higher education resource structure. The influence factors of the higher education resource structure optimization including the influence of social environment, the change of social class, economic development, political factors, the influence of institutions of higher learning discipline (speciality) replication mode and the influence of institutions of higher learning resources flow barriers. The core of establishing an appropriate and effective management mechanism for higher education lies in the structural optimization of various education resources.