No abstract

The first example of copper-catalyzed formylation of alkenyl C–H bonds with BrCHCl2 as a stoichiometric formylating reagent for the facile synthesis of α,β-unsaturated aldehydes has been developed.

An efficient nickel-catalyzed Heck-type reaction between styrenes and fluoroalkyl iodine has been developed. This novel transformation has demonstrated a broad substrate scope, mild reaction conditions and excellent E-stereoselectivity. This efficient synthetic method has been applied to the late-stage monofluoroacetation of biologically active molecules. Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.