A physiologic dimension appears to exist between the bone and the implant-crown interface around one-piece implants that is established early and maintained over time. These results are significant because they demonstrate in patients that the magnitude of initial bone remodeling around these one-piece dental implants is dependent on the positioning of the rough-smooth border of the implant in an apico-coronal dimension. Furthermore, the dimension, from the crown-implant interface to the first bone-to-implant contact, is consistent with the formation of a biologic width similar to that found around the natural dentition.

A previously uncharacterized human B-lymphocyte antigen has been detected by rabbit antisera raised to papain digests of spleen cell membranes. The unabsorbed sera reacted in both cytotoxicity and immunofluorescent tests with normal B lymphocytes and cultured B-cell lines but not with normal T lymphocytes or cultured T-cell lines. The cytotoxicity titers against B cells were as high as 1:32,000, whereas the same sera undiluted were negative against T cells. By immunofluorescent staining 6-14% of unfractionated normal lymphocytes and 48-85% of B-rich lymphocyte preparations were positive. Normal peripheral blood granulocytes, platelets, erythrocytes, and phytohemagglutinin blasts were negative. The antisera reacted with the same high titers against leukemia cells from approximately 70% of the patients with acute lymphocytic leukemia, acute myelocytic leukemia, chronic myelocytic leukemia, and seven of eight cases of chronic lymphocytic leukemia. From absorption studies it appeared that the same antigen was being expressed by leukemia cells and normal B lymphocytes. Using immunofluorescent staining the anti-B-cell antisera were able to detect positive leukemia cells in the bone marrow of patients with advanced leukemia and to monitor the elimination of these cells after chemotherapy. Soluble B-cell antigen was found in the serum of some leukemia and lymphoma patients do but not in normal serum.

Transient erythroblastopenia of childhood is a relatively uncommon disorder of infants and young children. It is characterized by a profound but transient cessation of erythropoiesis followed within a few weeks or months by complete recovery (1).We have recently had the opportunity to study red cell enzymes in three children with this relatively rare disorder and to compare