Trichomonas vaginalis causes trichomoniasis, second most sexually transmitted disease. The genome sequence draft of T. vaginalis was published by The Institute of Genomic Research reveals an abnormally large genome size of 160 Mb. It was speculated that a significant portion of the proteome contains paralogous proteins. The present study was aimed at identification and analysis of the paralogous proteins. The all against all search approach is used to identify the paralogous proteins. The dataset of proteins was retrieved from TIGR and TrichDB FTP server. The BLAST-P program performed all against all database searches against the protein database of Trichomonas vaginalis available at NCBI genome database. In the present study about 50,000 proteins were searched where 2,700 proteins were found to be paralogous under the rigid selection criteria. The Pfam database search has identified significant number of paralogous proteins which were further categorized among different 1496 paralogous protein in pfam families, 1027 paralogous protein contains domain, 60 proteins were having different repeats and 1092 paralogous protein sequences of clans. Such identification and functional annotation of paralogous proteins will also help in removing paralogous proteins from possible drug targets in future. Presence of huge number of paralogous proteins across wide range of gene families and domains may be one of the possible mechanisms involved in the T. vaginalis genome expansion and evolution.

Among the different forms of livestock farming, dairying is considered as a "treasure" of the Indian rural economy. For the design and implementation of support programmes to promote dairy farming for rural development and for adoption of new technologies in dairy, profile of the dairy farmers is an important factor in developing countries like India. By considering this aspect the study was undertaken in Hisar district of Haryana. Among the 60 dairy farmers 73.3 per cent of respondents were middle aged with mean age of about 43 years. The respondents had fairly good formal education with mean value of 4.23 which indicates that majority (96.6%) of dairy farmers were literate. Family structure of dairy farmers was 65.0 per cent of the respondents belonged to joint families and 35.0 per cent to nuclear families. The family land holding ranged from 1 to 6 acres with a mean 2.60 acres. 43.3 per cent of the respondents preferred to have a herd size of 3-5 dairy animals. The respondents in general had poor social participation with mean value as low as 0.16. Further, majority of the respondents had low level of extension contact with mean value of 2.23. Mass media exposure of dairy farmers was also low with mean value of 2.65 which indicates majority (73.3%) of dairy farmers had low level of mass media exposure. However, economic motivation of dairy farmer was fairly high with mean value of 22.56. The dairy farmers in general had medium risk orientation with mean value 18.28.

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BACKGROUNDGoitre is one of the common features of thyroid disease presentation. Most of the thyroid nodules were found accidentally by Ultrasound and clinical evaluation. Historically chances of malignancy in Multinodular Goitre was very low compared to solitary nodular goitre.The objective of this study is to determine the incidence of occult malignancy in longstanding MNG.

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