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Biocompatible core–shell CoFe2O4@HAp magnetic nanoparticles were successfully prepared by a simple two-step hydrothermal process, and their physicochemical and magnetic properties were studied.

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In the present work, surface modification of iron oxide (Fe 3 O 4) nanoparticles with biocompatible fluorapatite (FAP) coating achieved by a simple method and its characterizations using XRD, TEM, FT-IR, DSC and VSM are reported. TEM images revealed the spherical morphology of Fe 3 O 4 nanoparticle and rod-like FAP coated Fe 3 O 4 nanoparticles with size of about 12 and 30 nm, respectively. Magnetic measurements (M-H) of both the samples exhibited superparamagnetic behavior at 300 K. FAP coated Fe 3 O 4 nanoparticles enhance the cell viability and colloidal stability when compared to Fe 3 O 4 nanoparticles. These results demonstrate that FAP coated Fe 3 O 4 nanoparticles could be a suitable candidate for biomedical applications.