Introduction: To characterize cardiac complications in acute ischemic stroke (AIS) patients admitted from an urban emergency department (ED). Methods:Retrospective cross-sectional study evaluating AIS patients admitted from the ED within 24 hours of symptom onset who also had an echocardiogram performed within 72 hours of admission.Results: Two hundred AIS patients were identified with an overall in-hospital mortality rate of 8% (n ¼ 16). In our cohort, 57 (28.5%) of 200 had an ejection fraction less than 50%, 35 (20.4%) of 171 had ischemic changes on electrocardiogram (ECG), 18 (10.5%) of 171 presented in active atrial fibrillation, 21 (13.0%) of 161 had serum troponin elevation, and 2 (1.1%) of 184 survivors had potentially lethal arrhythmias on telemetry monitoring. Subgroup analysis revealed higher in-hospital mortality rates among those with systolic dysfunction (15.8% versus 4.9%; P ¼ 0.0180), troponin elevation (38.1% versus 3.4%; P , 0.0001), atrial fibrillation on ECG (33.3% versus 3.8%; P ¼ 0.0003), and ischemic changes on ECG (17.1% versus 6.1%; P ¼ 0.0398) compared with those without.

IntroductionTo characterize cardiac complications in acute ischemic stroke (AIS) patients admitted from an urban emergency department (ED).MethodsRetrospective cross-sectional study evaluating AIS patients admitted from the ED within 24 hours of symptom onset who also had an echocardiogram performed within 72 hours of admission.ResultsTwo hundred AIS patients were identified with an overall in-hospital mortality rate of 8% (n = 16). In our cohort, 57 (28.5%) of 200 had an ejection fraction less than 50%, 35 (20.4%) of 171 had ischemic changes on electrocardiogram (ECG), 18 (10.5%) of 171 presented in active atrial fibrillation, 21 (13.0%) of 161 had serum troponin elevation, and 2 (1.1%) of 184 survivors had potentially lethal arrhythmias on telemetry monitoring. Subgroup analysis revealed higher in-hospital mortality rates among those with systolic dysfunction (15.8% versus 4.9%; P = 0.0180), troponin elevation (38.1% versus 3.4%; P < 0.0001), atrial fibrillation on ECG (33.3% versus 3.8%; P = 0.0003), and ischemic changes on ECG (17.1% versus 6.1%; P = 0.0398) compared with those without.ConclusionA proportion of AIS patients may have cardiac complications. Systolic dysfunction, troponin elevation, atrial fibrillation, or ischemic changes on ECG may be associated with higher in-hospital mortality rates. These findings support the adjunctive role of cardiac-monitoring strategies in the acute presentation of AIS.

Macrocyclic ethers are used extensively for their ability to form strong and selective interactions with charged species. It has been shown that the incorporation of heterocyclic groups into macrocylclic ethers increase rigidity and interaction with certain ions. Alkylation of these azacrowns with benzylic halides can attach fluorionophoric substituents onto the ring. One of the molecules used for this alkylation is 5-chloro-8-methoxy-2-͑bromomethyl͒quinoline. Azacrowns with this alkyl ligand have displayed interesting ion complexation properties.

No abstract

No abstract