These findings are in line with the concept that PHD-Is exert their protective effects through accumulation of HIF target gene products, with time requirements for increased transcription and translation of HIF-dependent genes, and suggest that their renoprotective effect is not predominately mediated by EPO.

No abstract

Esterification of 2,2‐bis(3,5‐dimethylpyrazol‐1‐yl)‐3‐hydroxypropionic acid (2) with methacryloyl chloride led to the new κ3‐N,N,O ligand 2,2‐bis(3,5‐dimethylpyrazol‐1‐yl)‐3‐methacrylato‐propionic acid (Hbdmpzmp) (3). The κ3‐N,N,O coordination as known from bis(3,5‐dimethylpyrazol‐1‐yl)acetic acid (Hbdmpza, 1) was proven by syntheses of the complexes [Mn(bdmpzmp)(CO)3] (4) and [Re(bdmpzmp)(CO)3] (5) and the single‐crystal X‐ray structure of 4. The methacrylic ester functionality makes 3, 4 and 5 suitable for polymerisation. Thus, copolymerisation of 3 with methyl methacrylate (MMA), a combination of MMA and ethylene glycol dimethacrylate (EGDMA) or pure EGDMA led to various solid phases (P1a–P1c, P2, P3a, P3b) with incorporated ligand. Polymer‐bound manganese and rhenium tricarbonyl complexes could be obtained by copolymerisation of 4 and 5 with MMA as well as by a polymer analogous reaction of P1a with appropriate metal salts. In both cases, the facial tripodal binding behaviour was evidenced by IR spectra of the polymer supported transition metal complexes and the uptake of manganese was proven by AAS measurements. Reaction of the soluble deprotonated solid phase P1a with copper(II) chloride led to a deep‐blue solid phase (P‐Cu‐I). The UV/Vis absorption maximum at 715 nm indicates the copper centres to act as crosslinking agent by a similar binding behaviour as in [Cu(bdmpza)2]. In contrast, the heterogeneous reaction of P1b with copper(II) chloride formed a lime‐green solid phase (P‐Cu‐II). The bathochromic shift of the absorption maximum by 78 nm suggests one‐sided bound copper centres. EPR spectra do not show exchange narrowing between the copper centres indicating the metal centres to be far enough apart from each other to prevent magnetic interactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

The new N,N,O ligand bis(3,5-dimethyl-4-vinylpyrazol-1-yl)-acetic acid (Hbdmvpza) (4) suitable for copolymerisation was synthesised in a multi-step synthesis starting from bis(3,5-dimethylpyrazol-1-yl)methane (1). The

The syntheses of the two dicarbonyl complexes [Ru(bdmpza)Cl(CO)2] (3) and [Ru(2,2-bdmpzp)Cl(CO)2] (4), bearing a bis(3,5-dimethylpyrazol-1-yl)acetato (bdmpza) or a 2,2-bis(3,5-dimethylpyrazol-1-yl)propionato (2,2-bdmpzp) scorpionate ligand, are described. Both complexes are obtained by reacting the polymer [RuCl2(CO)2] n with either K[bdmpza] or K[2,2-bdmpzp]. Reaction of the acid Hbdmpza with [Ru3(CO)12] results in the formation of two structural isomers of a hydrido complex, [Ru(bdmpza)H(CO)2] (5a,b). Under aerobic conditions conversion of [Ru(bdmpza)H(CO)2] (5a,b) to form the Ru(I) dimer [Ru(bdmpza)(CO)(μ-CO)]2 (6) seems to be hindered in comparison to the case for the η5-C5H5 (Cp) analogues. Dimer 6 is obtained via a reaction of Hbdmpza with catena-[Ru(OAc)(CO)2] n instead. The molecular structures of 3, 4, and 6 have been obtained by single-crystal X-ray structure determinations. The precatalytic properties of the two dicarbonyl complexes 3 and 4 toward the catalytic oxidation of cyclohexene with different oxidizing agents are discussed as well.