Background: In both nursing practise and education, nursing informatics is crucial. In order to increase the quality of care, it is important to focus on the educational needs of nurses in relation to nursing informatics.. Aim: Assess educational needs regarding nursing informatics and its relation to quality of care as perceived by nurses. Design: A descriptive correlational research design was used. Setting: Critical care units at Benha University Hospital. Subjects: Convenience sample included (418) nurses who had previously worked.. Tools of data collection: Two tools were utilized. I) Nursing informatics educational needs questionnaire. II) Quality of care questionnaire. Results: the highest educational needs regarding nursing informatics was related nursing skills (74.9%), followed by computer skills (72.7%), then information technology skills (69.1%) . Also (46.7%) of nurses perceived that educational needs of nursing informatics was high. About half of nurses reported that level of quality of care was high. Conclusion: There was negative statistically insignificant correlation between educational needs and quality of care. Recommendations: Hospital administrators need to conduct inservice training, workshops, seminar to increase awareness,gain support and engagement of nurses about nursing informatics.