The proteomic content of the endometrial fluid (EF) from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail.This study is a comparative untargeted lipidomic analysis of human EF obtained from 35 patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography coupled to mass spectrometry. A total of 123 out of the 457 metabolites identified in the EF were found to be significantly differentially expressed between ovarian endometriosis (OE) versus controls. Univariate statistical analysis showed reduced levels of saturated diacylglycerols and saturated triacylglycerols in endometriosis patients. A predictive model was generated using the 123 differentially expressed metabolites. Using this model, we were able to correctly classify 86% of the samples. This study identified the lipidomic profile in the EF associated with OE, suggesting that EF analysis could be considered as a minimally invasive approach for the diagnosis of endometriosis. In conclusion, the lipidomic profile of the EF is different between samples from patients with OE and controls.

Las nuevas tecnologías, y en particular internet, suponen un reto para la actividad educadores de los padres. El presente artículo pretende mostrar el modo en el que los padres y las madres afrontan esta situación a partir del análisis de las estrategias de mediación que aplican a sus hijas e hijos en el uso de internet. Los resultados que se muestran se basan en los datos de la encuesta realizada por EU Kids Online en España. La encuesta en España se realizó sobre una muestra de 1.024 menores de entre 9 y 16 años, y uno de sus padres, aquel de los dos "que estuviese más implicado o tuviese un mayor conocimiento de la actividad que su hijo o hija desarrollaba en Internet". Las familias en las que se desarrollaron las entrevistas se seleccionaron a partir de direcciones escogidas a través de procedimiento de rutas aleatorias. Las entrevistas tuvieron lugar en el año 2010. Los datos evidencian un uso muy extendido de estrategias de mediación activa, tanto en el uso como para la seguridad en internet, y restrictiva y una escasa presencia de las estrategias de carácter tecnológico o de seguimiento.

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In this work, polypropylene (PP)–clay nanocomposites obtained by melt blending were investigated. Different commercial montmorillonites (MMTs), such as unmodified MMT, octadecyl ammonium-modified MMT, and dimethyl dialkyl ammonium-modified MMT, have been used. Maleic anhydride–polypropylene (MAPP) copolymer has been used as a coupling agent, and the effect of clay modification as well as MMT: MAPP ratio on final nanocomposites performance was studied. The transmission electron microscopy was used to evaluate the incorporation of clays into the PP matrix. The isothermal crystallization behavior of neat PP and different nanocomposites was studied by differential scanning calorimetry and polarized optical microscopy. Only nanocomposites based on organically modified MMT showed mechanical performance improvements. Nanocomposite reinforced with 5 wt% of organically modified MMT without MAPP showed modulus and strength values of 871 and 29.3 MPa, respectively, these values being higher, around 23% and 4.6%, respectively, than modulus and strength values of neat PP. The incorporation of MMT into the PP matrix produced an increment on the crystallinity rate with respect to neat PP. The half crystallization time of nanocomposites without MAPP was, at least, two times faster than for a neat PP system.