Natural porous materials adjust their resulting mechanical properties by the optimal use of matter and space. When these are produced synthetically, they are known as mechanical metamaterials. This paper adds degrees of tailoring of mechanical properties by producing double levels of gradation in lattice structures via cross-section variation in struts in uniformly periodic lattice structures (UPLS) and layered lattice structures (LLS). These were then additively manufactured via material extrusion (ME) and vat photopolymerization (VP). Their effective mechanical properties under compressive loads were characterized, and their stiffness contrasted with finite element models (FEM). According to the simulation and experimental results, a better correlation was obtained in the structures manufactured via VP than by ME, denoting that printing defects affect the correlation results. The brittle natural behavior of the resin caused a lack of a plateau region in the stress–strain curves for the UPLS structures, as opposed to those fabricated with ME. The LLS increased energy absorption up to % and increased the plateau stress up to % compared to the UPLS. The results presented in this paper demonstrate that the mechanical properties of lattice structures with the same base topology could be modified by incorporating variations in the strut diameter and then arranging these differently.