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The profile of mutations in the CFTR gene, which reflects the heterogeneity of its inhabitants, shows the complexity of the molecular diagnosis of CF mutations in most of the Latin American countries.

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We report the first specific human immunoglobulin subclass probe which was obtained by subcloning the gamma 3 hinge region. This specific y3 probe allowed us to identify with certainty the Cy3 gene on Southern genomic blots, to describe the first Cy3 restriction fragment length polymorphism (EZZ y3 RF) and to show that an IgG3 selective deficiency, previously described serologically, was not due to a deletion of the Cy3 gene. Such a probe should be particularly useful for screening libraries from individuals with IgG3 immunodeficiencies or presenting unusual Cy3 genes and, consequently, for studying the Cy gene evolution.