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Summary The objective of this study was to apply Hotelling's T2‐statistics to color measurement data of colored coatings. It is described, how outliers can be detected by comparing T2 with an appropriate statistical distribution function. As an example, the precision in the reproduction of colored coatings produced in laboratory and prepared by a robot for high‐throughput experimentation was investigated on a turquoise coating. After elimination of outliers the precision of reproduction of the coatings color was determined by the sample color differences to the average color coordinates in CIELAB and DIN99 color spaces as well as with CIEDE2000 color differences. As expected, laboratory experimentation (reproducibility conditions) showed a lower precision of color reproduction as samples prepared with the high‐throughput experimentation device (repeatability conditions).