No abstract

No abstract

No abstract

Some ketones, especially 2,3-trans-3,4-cis-trisubstituted cyclopentanones, have strong inherent preferences to react through their less-substituted enolates, with neither kinetic nor thermodynamic conditions being able to selectively functionalize their moresubstituted enolate isomers. Herein we report a synthetic strategy to overcome this limitation and selectively access the more-substituted alkylation products of these ketones. The strategy's key feature is to utilize a MeOCH 2 O group to temporarily block the more-reactive α position and to direct the ketone to react through its inherently less-reactive enolate isomer. The products formed by this strategy are useful synthetic intermediates on the path to multiple families of natural products.

A gifted-child workshop is also in keeping with the present trend and can yield many practical suggestions for changing classroom practices. A resource-use workshop in which the group studies better ways for the use of human and natural resources obviously has unlimited possibilites. Most systems now have some kind of a training period for the nonteaching staff, in which the cafeteria, the custodial, and transportation personnel are trained. A few systems have help workshops to which laymen were invited and have felt that the added understanding was well worth the effort. Some have thereby recruited board members who went to bat for them with the city fathers and at the polls.