In previous investigations 1 it was observed that the antistreptolysin titer of infants at the onset of infections was lower than that of older persons and that their antistreptolysin response to infection with beta hemolytic streptococci was minimal. Furthermore, Wilson, Wheeler and Leask 2 observed that the average antistreptolysin titer of a group of new-born infants (56 units)3 was approximately that of their mothers (50 units). Repeated determinations showed that the mothers' titers remained at a constant level while those of the infants diminished pro-

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