In the era of radical socio-economic-technological developments, the Library and Information Science sector in Greece is undergoing a series of changes in a dialectic relation with technological changes. Libraries in Greece have a long history, from the Academy of Plato and the Lyceum of Aristotle in the 5th century BC to the transition of the National Library of Greece at the Stavros Niarchos Foundation Cultural Centre. This paper aims to provide an overview and record the milestones signifying the beginning of the changes happening in every aspect of the Greek LIS landscape. In addition, it aims to highlight the changes in the Greek library scene, extending from synergies and networks to new library buildings, as well as the role of LIS education and lifelong learning.