A tutorial review aimed to introduce natural product chemists to the predictions of natural product configurations by ECD and OR calculations.

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.

Feature based molecular networking was used to compare chlorinated metabolites of S. aurea and Trichodesmium sp. and revealed four new antiproliferative polyketides.