The composition of the volatiles from leaves of Cinnamomum zeylanicum Blume from Sri Lanka was studied by GC-FID and GC-MS. The basic component of the oil was found to be eugenol (74.9%), followed by β-caryophyllene (4.1%), benzyl benzoate (3.0%), linalool (2.5%), eugenyl acetate (2.1%) and cinnamyl acetate (1.8%). The essential leaf oil from cinnamon demonstrated scavenger activity against the DPPH radical at concentrations which are lower than the concentrations of eugenol, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA). This essential cinnamon oil showed also a significant inhibitory effect on hydroxyl radicals and acted as an iron chelator. Cinnamon leaf oil efficiently inhibited the formation of conjugated dienes and the generation of secondary products from lipid peroxidation at a concentration equivalent to that of the standard BHT.

This work deals with the use of organic systematic nomenclature in scientific literature, its quality, and computerized methods for its improvement. Criteria for classification of systematic names in terms of quality/correctness are discussed and applied to a sample set of several hundred names extracted from the literature. The same structures are named with three popular state-of-the-art nomenclature programs -AutoNom 2000, ChemDraw 10.0, and ACD/Name 9.0. When comparing the results, all nomenclature tools show a significantly better performance than 'average chemists'. One program allows the generation not only of IUPAC names but also of CAS-like index names that are compared with the officially registered names. The scope and limitations of nomenclature software are discussed and a comparison of the programs' actual capabilities is given.

A S h o r t S y n t h e s i s o f P y r i d o [ 5 , 6 ] p y r a n o [ 2 , 3 -c ] p y r a z o l -4 ( 1 H ) -o n e s Abstract: An efficient and generally applicable synthesis of various [5,6]pyrano[2,3-c]pyrazol-4(1H)-ones by the reaction of either 1-substituted or 1,3-disubstituted 2-pyrazolin-5-ones with different o-halopyridinecarbonyl chlorides or with 3-chloroquinoline-2-carbonyl chloride, using calcium hydroxide in 1,4-dioxane, is described.In the course of the preparation of pyrazolo[4¢,3¢:5,6]pyrano[2,3-c]pyridin-4(1H)-ones, the intermediate 4-(3-chloroisonicotinoyl)-1H-pyrazol-5-ols did not cyclize spontaneously and thus were transformed into the corresponding tricycles by treatment with NaH in DMF. The N1-unsubstituted title compounds were obtained upon treatment of the corresponding 1-(4-methoxybenzyl) protected congeners with trifluoroacetic acid. Table 4 Selected 13 C-1 H Spin-Coupling Constants (Hz) of 7a-c, 7f, 8a-c, 9a-c, 10a-e, 11f (Solvents as in Table 28a other couplings G. A. Eller et al. PAPER Synthesis 2006, No. 24, 4219-4229 © Thieme Stuttgart · New York 1 H NMR (300 MHz, DMSO-d 6 ): d = 7.67 (m, 3 J

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Abstract:Starting from commercially available educts, a straightforward synthetic route to new heterocyclic building blocks is exemplified with the one-or two-step synthesis of tri-, tetra-, or pentacyclic ring systems. Representatives of the following novel ring systems are prepared from 3-methyl-1-phenyl-2-pyrazolin-5-one and the corresponding o-haloarenecarbonyl chloride using calcium hydroxide in refluxing 1,4-dioxane: pyrimidino [4',5':5,6] While the latter two ring systems are directly obtained due to a spontaneous intramolecular substitution reaction, in the other reactions uncyclised 4-aroylpyrazol-5-ols are produced, which are cyclised into the target heterocycles in a subsequent synthetic step (i.e. treatment with NaH in DMF). Detailed NMR spectroscopic investigations ( 1 H-, 13 C-, 15 N-) with the obtained compounds were undertaken to unambiguously prove the new structures.