A short, simple and economical process for large-scale preparation of nabumetone has been developed. The single-crystal
structures of nabumetone and one of its key intermediates have
been determined by X-ray diffraction studies. Two impurities
have been isolated and characterised.
ethers ethers (naphthalene compounds) Q 0890
-105Process Research and Structural Studies on Nabumetone.-A short, simple and economical process for the large-scale preparation of the drug nabumetone (IV) is described. The single crystal structures of (IV) and its key intermediate (III) are determined by X-ray diffraction studies. -(PRABHAKAR, C.; REDDY, G. BAKKI; REDDY, CH. MAHEEDHARA; NAGESHWAR, D.; DEVI, A. SIVALAKSHMI; BABU, J. MOSES; VYAS, K.; SARMA, M. R.; REDDY, G. OM; Org. Process Res. Dev. 3 (1999) 2, 121-125; Dep. Process Res. Dev., Dr. Reddy's Res. Found.,
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