This study assessed the social knowledge, attitude, and perceptions (KAPs) on wastewater treatment, the technologies involved, and its reuse across different wastewater treatment areas in four regions of Tanzania. We used both quantitative and qualitative data collection methods in a household-level questionnaire (n=327) with structured and semi-structured questions, which involved face-to-face interviews and observation. Our results show that social KAPs surrounding wastewater treatment and reuse were sufficient based on KAP scores achieved from asked questions. However, the general knowledge on treatment technologies, processes, and reuse risks was still low. Of the respondents, over 50% approved using treated wastewater in various applications, while the majority (93%) were reluctant if the application involved direct contact with the water. Furthermore, over 90% of interviewees did not know the technologies used to treat wastewater and the potential health risks associated with its use (59%). Multivariate analysis of variance revealed significant differences (P<0.05) in the KAPs on treated wastewater across different studied demographic variables, i.e., age, sex, and education level. Therefore, we recommend that more effort be spent on providing public education about the potential of wastewater treatment and existing technologies in order to facilitate their adoption for the community's and environment's benefit.