No abstract

Among many therapeutic treatments for cancer, nano-carriers are the focus of our review to illustrate the update usage of this drug delivery approach, the most likely side effects and the reality of their potential application with minimum adverse effects. Here, we demonstrate the types of these nano-carriers based on their nature with detailed recent studies about their use. The variation in the skeleton of these nanoparticles enable the selection of the suitable type with higher specifications than others.  However, the poor in vivo testing is the main stumbling block for completion of their manufacturing. This review will help the researchers to find the road map for further investigation to finally aid the pharmaceutical companies in manufacturing these nano-carriers in appropriate dosage forms to save the life of millions of people in the world.

This study is unique in studying the thermogravimetric analysis (TGA) of poorly water-soluble drugs before their formulation. Three selected drugs atorvastatin, albendazole and diclofenac were mixed with three different polymers hydroxypropyl methylcellulose (HPMC), polyvinylpyrrolidone (PVP) and soluplus (SOL). The pure drugs and physical mixtures were subjected to solvent evaporation and milling techniques to obtain solid dispersions. All, as received and TGA analyzed solid dispersion mixtures to evaluate their thermal behavior at a temperature that ranged from 0–300°C. The results showed that the addition of polymer either in physical mixtures or solid dispersions of the drugs has resulted in either increase or decrease of the thermal stability of the drugs depending on the method of preparation and the type of the polymer and the nature of the drug.

A high percentage of active pharmaceutical ingredient are available in the insoluble crystalline phase.  During pharmaceutical processing such as milling there are many issues can be initiated due to the transformation of this crystalline materials. Some trans-formation might be positively solving the active pharmaceutical ingredients (APIs) problems such as solubility and dissolution rate while others might negatively affect these factors which render the APIs into inactive compound. Therefore, during the pre-formulation study, all of these issues must be resolved to ensure drug stability and hence its bioavailability. This review will shed the light on the most popular transformations that happened, factors affecting them, and the characterization methods used for the detection of phase formed. The studying of these factors, will help to avoid them in future