Introduction: Several chemotherapeutic drugs are known to be teratogenic and mutagenic to humans. Nurses are the main group of health care workers that are exposed to these drugs during their work. Generally, the work activities that pose the greatest risk of exposure are the preparation and administration of antineoplastic drugs, and cleaning of chemotherapy spills. Aim of work: 1) To estimate the prevalence of hazardous effects to which nurses handling cytotoxic drugs (CDs) are exposed 2) To evaluate the current safety measures used in clinical practice and 3) To assess nurses' knowledge regarding cytotoxic Drugs.