Love in the Time of Cholera (1988) deals with the theme of love. In this novel, Garcia Marquez has represented love in various scenarios and through different characters. The novel projects every kind of love, such as; parental love, love for the opposite sex, and domestic love, yet love is not projected as a sweet and subtle emotion. This study has traced the elements of the destructive and deteriorative influence of love, which are analytically discussed in detail. The study is a selected work as it is limited to the mentioned novel. The method of research is Relational Analysis (1992) by Carley from the paradigm of Content Analysis wherein the tools of analysis are theme, characters, symbols and title. The novel is analyzed through the theoretical framework of Readers Response Theory by Rosenblatt (1995). Findings of the study have led to the conclusion that love has been projected as a destructive and devastating stimulus in the novel.