Background: Diabetic ketoacidosis (DKA) is defined by high blood glucose, metabolic acidosis and increased ketone concentration in the body. It is a serious and potentially fatal complication of diabetes mellitus (DM). The study aimed to determine the socio-demographic and clinical characteristics of patients with DKA. Methods: A retrospective cross-sectional study design was conducted in Madinah general hospital in Madinah, Saudi Arabia. Medical records were reviewed for all DKA patients admitted to the hospital from January 2019 to October 2022. Socio-demographic and clinical characteristics of diabetic ketoacidosis were retrieved for eligible patients. Results: Out of 260 files reviewed, only 258 were included. Participants' mean age was 35.6 ±19.4. Most participants had type 1 DM (62%). The main precipitating factors of DKA were infection (44.5%) and non-compliance (29.8%). Vomiting (71.3%) and abdominal pain (56.9%) were the most common clinical manifestations. Conclusion: The main leading precipitating factors of DKA were infection and non-compliance to treatments. The most frequent clinical manifestations in diabetic patients with ketoacidosis were vomiting and abdominal pain.