Objectives: To determine the frequency of neurological manifestations of vitamin B12deficiency and to observe the reversibility of the symptoms after the therapy. Study Design: Descriptivestudy. Study Design: Descriptive study. Setting: Medicine Department of Bolan Medical Complex HospitalQuetta. Period: One year that is from January 2012 to December 2012. Methodology: 46 patients presentedto various OPDS of B.M.C.H.. The inclusion criteria for the patients to be studied were: Anemia, Neurologicalcomplaints. Results: Out of 46 patients 26(56%) were males and 20(43%) were the females with a meanage of (40) years.32 (69%) belonged to the rural areas. 45(97%) had mixed diets whereas only one 1(2.1%)young non Muslim was found to be pure vegetarian.32 (69%) patients presented with hematological aswell as neurological complaints. 23(30%) had pancytopenia and 9(19.5%) had bicytopenia. 14(30%)presented with neurological complaints only as sacd 6 (13%), ataxia 8 (17%), sensorimotor neuropathies36 (78%) and dementia 2 (4.3%). In signs glossitis was found in 6(13%), jaundice in 22 (47%), pallor in32 (69%) proximal myopathy in 12 (26%) out of which 6 (13%) had shoulder girdle and 8 (17%) pelvicgirdle myopathy. Impaired position sense was found in 18 (39%) patients and vibration sense in 21(45%)patients. other signs were pigmentation 2(4.3%) hypotonia in 6(13%) Spasticity in 2(4.3%) and Upgoingplantars in 6(13%) patients. Lhermittes sign could be elicited in only 2(4.3%) patients Optic neuritis andoptic atrophy was found in 4(8.6%) patients who came with paraplegia and marked anemia. Rhombergssign was positive in 8(17.3%) who came with clumsiness of gait. Hemoglobin (Hb %) was found to be lowin 32(69%) with a mean of 7.2gm%.pancytopenia (anemia+leucopenia+thrombocytopenia) was found in23(50%) of patients whereas bicytopenia was found only in 9(19.5%) of patients. Hypersegmented W.B.Cwere very carefully looked for and were found in 20(43%) of cases. ovalomegaloblasts were found in 32(69%) of cases .both findings of ovalomegaloblasts and hypersegmented w.b.cs were found in 20 (43%).in the rest 14 (30%) the blood investigations were found to be normal. The next investigation in all patientswas serum B12 estimation, It was found that levels below 200pg/ml were found in 95% cases where only2(4.3%) patients came with levels slightly above 205pg/ml and 210pg/ml. the response to therapy wasrecorded as reversible and irreversible. the irreversible features were sacd in 6 (13%), optic atrophy in2 (4.3%), and dementia in 2 (4.3%) patients. the partially reversible features were myelopathy 10 (21%)numbness and paraesthesias 30 (65%) optic neuritis inn 2 (4.3%) patients were assessed on a durationof 24 weeks. partially reversible features were ataxia, in 6 (13%) patients myelopathy in 2 (4.3%) patientsdementia in 2 (4.3%) patients and paraesthesias and numbness in 6 (13%) patients over a period of 24weeks. Conclusion: It is concluded from my study that the neuropsychiatric manifestations of vitamin B12deficiency are common among the elderly age group, either with or with out the evidence of anemia.

NAFLD is an emerging problem in Asia, with raising prevalence and strong impact on the health care system. More and more people will suffer from not only the liver impairment of NAFLD but also the associated metabolic diseases e.g. DM and hypertension. The incidence of DM, hypertension, coronary heart diseases (CHD) and stroke will increase together with the prevalence of NAFLD and the health service expenditure will rise in coming decades. However the prevalence of and the metabolic diseases associated with NAFLD are not well studied in Asian populations. The objective of this project is to systematically review the articles related to NAFLD.

Background: Pregnancy-induced hypertension (PIH) develops after 20 week of pregnancy in women who originally had no blood pressure. The complication arising of PIH may possibly affect both the mother and her fetus. Aims of the study: This study aims to assess the complications of pregnancy-induced hypertension; and to determine the relationship between complications of pregnancy inducing hypertension of pregnant women with their demographic characteristics. Methodology: A descriptive study was done for assessing complications of pregnancy-induced hypertension for pregnant women. The study started in the period of September 26th, 2020 to May, 20th, 2021. A non-probability (Purposive) sample of 100 pregnant women were attending the Al Basra Maternity and Children Hospital in AL-Basra Governorate. A questionnaire consists of two part include demographic data and complications of pregnancy, which are include "complications diagnosed for the pregnant mother; and complications diagnosed on fetus which composed (17) complications". The reliability of the questionnaire was determined through a pilot study and the validity through a panel of experts. The data were collected by questionnaire and interview. The data were described statistically and analyzed using descriptive and inferential statistical analysis procedures. Results: The results illustrated that there are low mean of score in all items of assessment related to complications of pregnancy inducing hypertension for pregnant women, a moderate level of mean of score for assessment concerning diagnosed complications on the fetus. The occupation, daily work and it nature were significantly relationship with their complications. Conclusion: There was a significant relationship between complications of pregnancy inducing hypertension of pregnant women and their age, occupational status, nature of work, and daily working hours, also, most of the complications (Lack of fluids surrounding the fetus, preterm labor, pre-eclampsia, renal failure, Loss of consciousness) have a significant relationship of pregnancy-induced hypertension. Recommendations: Adequate awareness regarding the reduction of pregnancy complications can also help to reduce the chances of malpractice as well as, manual booklet of complications of pregnancy and how to manage it should be write in simple words and use attractive pictures given to the women and family which indeed decreased pregnancy complications.

ORIGINAL PROF-3859 ABSTRACT… Objectives: To determine the frequency of neurological manifestations of vitamin B 12 deficiency and to observe the reversibility of the symptoms after the therapy. Study Design: Descriptive study. Study Design: Descriptive study. Setting: Medicine Department of Bolan Medical Complex Hospital Quetta. Period: One year that is from January 2012 to December 2012. Methodology: 46 patients presented to various OPDS of B.M.C.H.. The inclusion criteria for the patients to be studied were: Anemia, Neurological complaints. Results: Out of 46 patients 26(56%) were males and 20(43%) were the females with a mean age of (40) years.32 (69%) belonged to the rural areas. 45(97%) had mixed diets whereas only one 1(2.1%) young non Muslim was found to be pure vegetarian.32 (69%) patients presented with hematological as well as neurological complaints. 23(30%) had pancytopenia and 9(19.5%) had bicytopenia. 14(30%) presented with neurological complaints only as sacd 6 (13%), ataxia 8 (17%), sensorimotor neuropathies 36 (78%) and dementia 2 (4.3%). In signs glossitis was found in 6(13%), jaundice in 22 (47%), pallor in 32 (69%) proximal myopathy in 12 (26%) out of which 6 (13%) had shoulder girdle and 8 (17%) pelvic girdle myopathy. Impaired position sense was found in 18 (39%) patients and vibration sense in 21(45%) patients. other signs were pigmentation 2(4.3%) hypotonia in 6(13%) Spasticity in 2(4.3%) and Upgoing plantars in 6(13%) patients. Lhermittes sign could be elicited in only 2(4.3%) patients Optic neuritis and optic atrophy was found in 4(8.6%) patients who came with paraplegia and marked anemia. Rhombergs sign was positive in 8(17.3%) who came with clumsiness of gait. Hemoglobin (Hb %) was found to be low in 32(69%) with a mean of 7.2gm%.pancytopenia (anemia+leucopenia+thrombocytopenia) was found in 23(50%) of patients whereas bicytopenia was found only in 9(19.5%) of patients. Hypersegmented W.B.C were very carefully looked for and were found in 20(43%) of cases. ovalomegaloblasts were found in 32 (69%) of cases .both findings of ovalomegaloblasts and hypersegmented w.b.cs were found in 20 (43%). in the rest 14 (30%) the blood investigations were found to be normal. The next investigation in all patients was serum B 12 estimation, It was found that levels below 200pg/ml were found in 95% cases where only 2(4.3%) patients came with levels slightly above 205pg/ml and 210pg/ml. the response to therapy was recorded as reversible and irreversible. the irreversible features were sacd in 6 (13%), optic atrophy in 2 (4.3%), and dementia in 2 (4.3%) patients. the partially reversible features were myelopathy 10 (21%) numbness and paraesthesias 30 (65%) optic neuritis inn 2 (4.3%) patients were assessed on a duration of 24 weeks. partially reversible features were ataxia, in 6 (13%) patients myelopathy in 2 (4.3%) patients dementia in 2 (4.3%) patients and paraesthesias and numbness in 6 (13%) patients over a period of 24 weeks. Conclusion: It is concluded from my study that the neuropsychiatric manif...