The complexity of torsional load, its three-dimensional nature, its combination with other stresses, and its disruptive impact make torsional failure prevention an ambitious goal. However, even if the problem has been addressed for decades, a deep and organized treatment is still lacking in the actual research landscape. For this reason, this review aims at presenting a methodical approach to address torsional issues starting from a punctual problem definition. Accidents and breaks due to torsion, which often occur in different engineering fields such as mechanical, biomedical, and civil industry are considered and critically compared. More in depth, the limitations of common-designed torsion-resistant structures (i.e., high complexity and increased weight) are highlighted, and emerge as a crucial point for a deeper nature-driven analysis of novel solutions. In this context, an accurate screening of torsion-resistant bio-inspired unit cells is presented, taking inspiration specifically from plants, that are often subjected to the torsional effect of winds. As future insights, the actual state of technology suggests an innovative transposition to the industry: these unit cells could be prominently implied to develop novel metamaterials that could be able to address the torsional issue with a multi-scale and tailored arrangement.