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As reported by other workers, late pregnancy is accompanied by an insulin-resistant state, which is not clearly explained by rising of the so-called gestational hormones. The present study reports the results on insulin binding and insulin action on adipocytes from healthy, obese and diabetic pregnant women (17 s.) isolated during Caesarian section and in control non pregnant women (22 s.). Because plasma insulin increases during pregnancy, the hypothesis of a down regulation of insulin-receptor by circulating insulin is confirmed by this research.

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Twenty-six healthy premenopausal outpatients from the Menopause Clinic of the University of Bologna were treated with a combination pill containing 0.020 mg of ethinyl estradiol and 0.150 mg of desogestrel for one year. Throughout the treatment period, clinical and laboratory monitoring was periodically performed, and women were asked about the occurrence of climacteric symptoms. This formulation relieved climacteric symptoms, and did not adversely affect lipids and clotting factors, except for a slight increase in serum triglycerides. Laboratory data also suggest a beneficial effect on bone metabolism.