Derivatives of two novel, structurally related heterocyclic ring systems, xantheno[3,4-d]imidazole and chromeno[4,3,2-c,d]imidazo[4,5-f]indazole, bearing aminoalkyl side chains, have been synthesized, and their antiproliferative activity has been studied against the aggressive human breast MDA-MB-231 cell line. The pyrazole-fused analogue 27a possesses a pronounced antiproliferative effect on the tested cell line, evident at 1 muM, and achieves an IC50 of 6.5 microM.

<p>The present study, via the use of a questionnaire, examined the views of 138 Greek teachers, of general and special education, on the readiness for distance education, the challenges they face during the courses, and the measures to be taken in education in case of a next crisis such as Coronavirus pandemic (COVID-19). Educators’ views on the measures to be taken by educational institutions in order to be ready to provide distance education in the post-COVID era were also examined. The analysis of results showed that Special Education teachers appeared to be more ready for distance education; indeed, their field of employment itself, namely teaching, their years of service, the age and the level of studies were found to have a statistically significant influence on their answers. The greater challenge that both groups of teachers faced were the difficulties in communicating with their students. It became apparent also the great need for training teachers in issues related to distance education as well as the protection of their personal data of their students. </p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0977/a.php" alt="Hit counter" /></p>

The research presents the results from the completion of a questionnaire exclusively by the participants of the study who have been perpetrators of acts of bullying. The results showed that the bullies to a small extent acknowledged that they became bullies because they felt powerful, because they like to dominate/oppress others, because they wanted recognition of their authority from their classmates, because they were afraid of becoming victims and because they had had previously been victims of bullying (in all cases the average value is equal to 2.0). Also, the results showed that the most important reason that pushed the bullies to bully was some particular characteristic of the victim (Mean=3.0, SD=1.0) and to a lesser extent identity -ethnicity, race, sexual orientation- (Mean=2.0, SD=1.0, Mean=2.0, SD=1.0, Mean=2.0, SD=1.0) respectively. According to the perpetrators, they bullied more often boys (Mean=3.0, SD=2.0), and students of their school (Mean=3.0, SD=2.0). Finally, it emerged that the most frequent form of bullying was derogatory comments (Mean=3.0, SD=2.0) followed by physical violence (Mean=2.0, SD=1.0).<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0263/a.php" alt="Hit counter" /></p>