Resumo Em 1992, Bettelli, Bianchi-Streit e Giacomelli disponibilizaram um importante texto sobre a Física de Partículas para um contexto educacional de escola básica, o Ensino Médio. Assim, neste artigo, é apresentada uma tradução comentada e adaptada desse texto, em que serão apresentados conceitos básicos para ensino e aprendizagem de Física de Partículas. Há também uma relevância histórica, porque apresenta a descoberta de algumas partículas e os princípios físicos envolvidos. As evidências das partículas novas e outras já conhecidas são fundamentadas na análise de fotografias de câmaras de bolhas, nas quais ficam registrados os eventos da física de altas energias. Nessas análises, foram utilizados conceitos e equações de Física Básica, Relatividade Restrita e Física Quântica, em especial os princípios de conservação. Desta forma, os professores e estudantes do Ensino Médio Brasileiro terão à disposição um interessante texto, com informações de fatos experimentais, para iniciar ou ampliar seu conhecimento sobre a Física Nuclear e de Partículas.

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How to cite: KOOLING J ET AL. 2019. Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na + , K + -ATPase activities found in the spleen from streptozotocin-induced diabetic rats. An Acad Bras Cienc 91: e20181330.Abstract: Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1d pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na + , K + -ATPase activity. Wistar rats were divided into non-diabetic groups: Control, ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments. diabetes was induced by a single dose of 60 mg/kg of streptozocin intraperitoneally, and treatments by intragastric gavage once daily for 60 days. Hyperglycemia reduced creatine kinase activity, which was reversed by the administration of resveratrol. Na + , K + -ATPase activity was greatly affected, but it was reversed by resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin. This suggest an energetic imbalance in the spleen of diabetic rats, and in case this also occurs in the diabetic patients, it is possible that resveratrol supplementation could be beneficial to the better functioning of the spleen in diabetic patients.

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