Endogenous endophthalmitis occurs in the setting of an intraocular infection secondary to the spread of bacterial, viral, or fungal pathogens with a high likelihood of permanent vision loss if left untreated. This case describes a 33-year-old male with numerous risk factors presenting with sudden onset of symptoms consistent with endogenous endophthalmitis secondary to Streptococcus beta-hemolyticus group G bacteremia of unknown source. He was treated with broad-spectrum antibiotics and analgesics with improvement in symptoms.