Cancer caregivers in Mexican American families experience role-related challenges influenced by limited healthcare literacy. The lack of functional health literacy becomes complex when Mexican Americans have limited English proficiency (LEP) and cultural beliefs that contrast with those of the American healthcare system. Three sequential studies focused on assessing the experience of Mexican American, female cancer caregivers, including their role learning needs; evaluating available community learning materials; and identifying healthcare provider perceptions of caregiver learning needs. Study findings provide direction to improve the process and content of teaching to caregivers with LEP and other caregivers facing the crisis of cancer. Practice recommendations focus on development of targeted learning materials appropriate to caregiver-identified learning needs, language, and education level. Priority learning needs include strategies to meet patient needs for home medication administration, nutrition, and psychological support. Caregiver-preferred formats for learning include videotapes in a family-assisted setting and oral exchanges with other caregivers and care providers. Bilingual clinic personnel who partner with Mexican American family caregivers to address their literacy issues support positive health outcomes in this vulnerable population. Healthcare Literacy:Multiple Perspectives Grounded in the Experience of Mexican American Caregivers At a GlanceF Mexican American family caregivers experience role-related challenges influenced by limited health literacy and English proficiency, both of which block the understanding necessary to deliver high-quality care to their family members with cancer.F Priority learning needs of Mexican American family cancer caregivers include ways to meet patient medication, nutrition, and psychological needs to support positive patient and caregiver outcomes during cancer treatment.F Limited cancer information in formats accessible for Mexican American caregiver learning offers an opportunity for healthcare professionals, including nurses, to develop targeted materials and interventions that optimally meet the learning needs of Mexican American cancer caregivers.