No abstract

Enomoto F, Ichikawa G, Nagaoka I, Yamashita T. Effect of erythromycin on otitis media with effusion in experimental rat model. Acta Otolaryngol (Stockh) 1998; Suppl 539: 57-60.To understand the mechanism of erythromycin (EM) on otitis media with effusion, we examined its effects on leukocyte accumulation and expression of adhesion molecules L-selectin and Mac-1, using a rat experimental model. Administration of EM inhibited leukocyte (neutrophil) accumulation in the middle ear cavity after LPS stimulation. Moreover, EM downregulated L-selectin expression and inhibited interleukin (IL)-8-induced upregulation of Mac-1 on peripheral blood neutrophils. These finding suggests that EM may improve otitis media with effusion by inhibiting neutrophil accumulation in the middle ear cavity through modulating the expression of adhesion molecules L-selectin and Mac-1 on peripheral blood neutrophils.

No abstract

No abstract

No abstract