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The paper presents an overview of some common issues related to the seismic isolation technique applied to existing RC buildings. At first, the issues considered are briefly described. Then, solutions on how to solve them are illustrated with reference to case studies on which the seismic isolation is applied. The interventions are to date only designed or in progress of being realized. All case studies considered are existing RC structures designed only for vertical loads with a non-ductile behaviour and located in Potenza, a city in the South of Italy in a high seismic hazard area.