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Among the carbon capture and storage (CCS) technologies suitable for power generation plants, partial oxy-combustion coupled with post combustion CO 2 capture is gaining interest, since such a hybrid configuration could allow to reduce the size and enhance the performance of postcombustion CO 2 capture by operating combustion with air enriched with oxygen and reducing the dilution of flue gas. Moreover, partial oxy-combustion is a potential candidate for the retrofit of existing steam plants because it could be based on an almost conventional boiler and requires a smaller CO 2 capture section. This work presents the results of a comparative techno-economic analysis of a 1000 MW th partial oxy-combustion plant based on an ultra-supercritical pulverized coal combustion power plant integrated with a post-combustion CO 2 capture system and geological storage in saline aquifer. In particular, plant performance is assessed by using simulation models implemented through Aspen Plus 7.3 and Gate Cycle 5.40 commercial tools, whereas economic performance are evaluated on the basis of the expected annual cash flow. The analysis shows that, for new plants, this hybrid approach is not feasible from the economic point of view and full oxy-combustion potentially remains the most profitable technology even if, in the short-term period, the lack of commercial experience will continue to involve a high financial risk.