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We propose a sub-set of men (with negative mpMRI, PSAD<0.15ng/mL/cc and prior negative biopsy) who may safely avoid re-biopsy. Conversely, PBx should be considered in biopsy-naïve men, regardless of negative mpMRI, particularly those with PSAD>0.15ng/mL/cc.

Based on the contemporary literature, our comprehensive meta-analysis indicates that robotic partial nephrectomy delivers mostly superior, and at a minimum equivalent, outcomes compared to open and laparoscopic partial nephrectomy. Robotics has now matured into an excellent approach for performing partial nephrectomy for renal masses.