No abstract

Receptor binding activity X 0280Pyrrolidinohydroquinazolines -A Novel Class of CCR3 Modulators. -A systematic study of new CCR3 modulators of type (I)-(IV) is performed. (IIa) gives the best results with compounds (IIb), (III) and (IV) showing essentially the same stimulation pattern. -(ANDERSKEWITZ*, R.; BAUER, R.; BODENBACH, G.; GESTER, D.; GRAMLICH, B.; MORSCHHAEUSER, G.; BIRKE, F. W.; Bioorg. Med. Chem. Lett. 15 (2005) 3, 669-673; Boehringer Ingelheim Pharma KG, D-88397 Biberach, Germany; Eng.) -M. Bohle 26-172