The mosquito of Aedes aegypti is the vector of the dengue virus can transmit the disease through bites DBD. The popular control in a society is by using chemical insecticides. The use of chemical insecticides can lead to continuous resistance of mosquitoes. The efforts to reduce the negative impact of chemical insecticides can be controlled with an insecticides plant. This control can be done by using materials that came from plant, one of them namely bitter melon (Momordica charantia L). The purpose of this research is to analyze the kill power of  bitter melon extracts against the mosquito of Aedes aegypti. This type of research is pure experiment with the design of the post test only control group design with five variants of extract concentration of 13%, 19%, 27%, 40%, and 59% with five repetitions. A kruskal wallis test result showed a difference in thye average number of deaths the mosquito of Aedes agypti in various concentration of bitter melon extract, indicated by the value of significance p=0,001 (p<0,05). The probit analysis obtained LC50 at 24,41% concentration and LC90 at 70,54% concentratin. The summary of this research, namely bitter melon extracts has the effect of insecticide against the mosquito of Aedes aegypti. Keywords: Aedes aegypti, insecticide, bitter melon